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Friday Dec 06, 2024
Friday Dec 06, 2024
The coefficient of inbreeding (COI) is a key tool used by breeders to quantify homozygosity and the risk of inherited disorders caused by recessive mutations. The inbreeding coefficient was derived in the 1920s by Sewell Wright, a statistician at the USDA. Breeders knew that inbreeding increased uniformity in offspring, but also caused genetic disorders and a loss of vigor (inbreeding depression). Consequently, they needed a way to predict the level of inbreeding in livestock. Wright's COI quantifies the degree of inbreeding, allowing breeders to balance these competing effects.
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