Episodes
Wednesday Dec 04, 2024
Why do dogs have more cancer than other mammals?
Wednesday Dec 04, 2024
Wednesday Dec 04, 2024
Large dogs have higher levels of cancer than small ones. This is predicted by "Peto's paradox", which argues that larger animals should have higher rates of cancer than small ones.
Suprisingly, however, larger mammals like elephants do not have higher rates of cancer than small mammals like rodents. The difference might be related to genes that suppress tumor growth. In fact, elephants have many copies of a tumor suppressor gene called TP53. Could the difference in cancer rates between dogs and other mammals be due to inadequate tumor suppression genes?
Suprisingly, however, larger mammals like elephants do not have higher rates of cancer than small mammals like rodents. The difference might be related to genes that suppress tumor growth. In fact, elephants have many copies of a tumor suppressor gene called TP53. Could the difference in cancer rates between dogs and other mammals be due to inadequate tumor suppression genes?
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